A first case report of dapsone inducing recurrent ventricular arrhythmia.
Bethany WongLavanya SaivaJohn BuckleyJoseph W GalvinPublished in: European heart journal. Case reports (2019)
The underlying mechanism for the association between dapsone treatment and VA is unclear and a prolonged QTc was not observed in our case. It is important to recognize that every drug has many physiological effects and in patients with underlying diseases whereby there is already an unfavourable environment, additional drugs can lower the threshold of triggering an arrhythmia and the result can be life-threatening. In a patient with ischaemic cardiomyopathy, where underlying substrate for VA may already exist, the introduction of dapsone could lower the threshold for development of arrhythmia.