The ongoing acquisition of large and multifaceted data sets in neuroscience requires new mathematical tools for quantitatively grounding these experimental findings. Since 2015, the International Conference on Mathematical Neuroscience (ICMNS) has provided a forum for researchers to discuss current mathematical innovations emerging in neuroscience. This special issue assembles current research and tutorials that were presented at the 2017 ICMNS held in Boulder, Colorado from May 30 to June 2. Topics discussed at the meeting include correlation analysis of network activity, information theory for plastic synapses, combinatorics for attractor neural networks, and novel data assimilation methods for neuroscience-all of which are represented in this special issue.