Correlation between immune-related Tryptophan-Kynurenine pathway and severity of severe pneumonia and inflammation-related polyunsaturated fatty acids.

Baojun GuoMingshan XueTeng ZhangHui GanRunpei LinMingtao LiuYuhong LiaoJiali LyuPeiyan ZhengBao-Qing Sun

Published in: Immunity, inflammation and disease (2023)

This study revealed that during severe pneumonia, the Tryptophan-Kynurenine pathway was activated and was positively correlated with the disease progression. On the other hand, the activation of the Tryptophan-Kynurenine pathway was negatively correlated with N-3/N-6 PUFAs.

Keyphrases

early onset
oxidative stress
drug induced
intensive care unit
respiratory failure