EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma.
Shiang-Fu HuangHuei-Tzu ChienSou-De ChengWen-Yu ChuangChun-Ta LiaoHung-Ming WangPublished in: BMC cancer (2017)
We can predict two-thirds of the EGFR gene copy number alterations in lymph node metastasis or recurrent tumors from the analysis of primary tumors. For OSCC patients who are unable to provide lymph node or recurrent tumor samples for EGFR gene copy number analysis, examining primary tumors could provide EGFR clonal information in metastatic, recurrent or SPT lesions.
Keyphrases
- copy number
- small cell lung cancer
- mitochondrial dna
- lymph node
- squamous cell carcinoma
- lymph node metastasis
- genome wide
- epidermal growth factor receptor
- tyrosine kinase
- dna methylation
- ejection fraction
- newly diagnosed
- healthcare
- papillary thyroid
- early stage
- social media
- locally advanced
- rectal cancer
- patient reported outcomes