Activation of NLRP3 Inflammasome via Drp1 Overexpression in Kupffer Cells Aggravates Ischemia-reperfusion Injury in Hepatic Steatosis.

Lu ZhangMingfu WangRan AnJun DaiShujun LiuMing Chen Hao-Ran Ding

Published in: Journal of clinical and translational hepatology (2023)

Kupffer cells aggravated IRI in hepatic steatosis via NLRP3 and Drp1. Drp1 inhibitors might be useful as specific therapeutics to alleviate IRI in hepatic steatosis and may have promise in case of liver donor shortage.

Keyphrases

nlrp inflammasome
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
oxidative stress
big data
artificial intelligence