Combined MEK/PD-L1 Inhibition Alters Peripheral Cytokines and Lymphocyte Populations Correlating with Improved Clinical Outcomes in Advanced Biliary Tract Cancer.

Amanda N Ruggieri Mark Yarchoan Subir Goyal Yuan Liu Elad Sharon Helen X Chen Brian M Olson Chrystal M Paulos Bassel F El-Rayes Shishir K Maithel Nilofer S Azad Gregory B Lesinski

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

This work represents a comprehensive analysis of peripheral immune features in patients with BTC and systemic responses to dual MEK/PD-L1 inhibition. These data support further investigation to understand how MEKi combines with immunotherapeutic approaches to improve clinical outcomes for patients with advanced BTC.

Keyphrases

pi k akt
papillary thyroid
chemotherapy induced
electronic health record
peripheral blood
big data
squamous cell
squamous cell carcinoma
signaling pathway
machine learning
artificial intelligence
young adults