Latest Advances in Determination of Bisphenols with Nanomaterials, Molecularly Imprinted Polymers and Aptamer Based Electrochemical Sensors.

Contamination of environmental sources such as soils, sediments and rivers and human exposure caused by several endocrine disrupting compounds (EDCs) are considered as the most challenging issues of today's world. EDCs cover a wide variety of compounds ranging from phthalates to parabens and bisphenols (BPs) are the leading group among them. BPs are widely used during the production of different plastic materials such as food and beverage containers, toys, medical equipment and baby bottles that we use in every aspect of our lives. BPs may migrate from those products to different media under certain conditions and this situation causes chronic exposure for humans and other creatures in the environment. Especially bisphenol A (BPA) and its other analogues such as bisphenol F, bisphenol S and tetrabromobisphenol that have similar structures and are preferred as alternatives to BPA cause harmful adverse effects such as endocrine disruption, neurotoxicity, genotoxicity and cytotoxicity. There are legal restrictions and prohibitions by the European Union (EU) in order to prevent possible harmful effects. Therefore, it is important to develop highly sensitive, fast, easy to use and cheap sensors for the determination of BPs in biological, environmental and commercial samples. Electrochemical sensors, which are one of the most widely, used analytical techniques, provide these conditions. Additionally, it is possible to enhance the performance of electrochemical sensors with nanomaterials, molecularly imprinted polymers or aptamer based technologies. This review aims to give comprehensive information about BPs with summarizing most recent applications of electrochemical sensors for their determination in different samples.