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Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N -Aryl Isoindolinones.

Valerio MorlacciTonino CarusoMarco ChiariniAntonio ArcadiMassimiliano AschiLaura Palombi
Published in: Molecules (Basel, Switzerland) (2022)
An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3- N -aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.
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