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Telangiectatic osteosarcoma in four dogs: Cytologic, histopathologic, cytochemical, and immunohistochemical findings.

Laura A CagleMorgan MaiselFrancisco O ConradoCourtney WaitKatherine PeperTannis LochheadThao VoJacqueline K DolanHelena Hauck de OliveiraSarah BoschRandall WalkerStacey A Fox-AlvarezErin PorterSheila Carrera-JustizChristopher J LanierAline Rodrigues HoffmannMichael J DarkLeslie C Sharkey
Published in: Veterinary clinical pathology (2024)
Telangiectatic osteosarcoma is a rare variant of osteosarcoma histologically and clinically similar to hemangiosarcoma (HSA). This case series describes the imaging and cytologic features of four histologically confirmed telangiectatic osteosarcomas, including the use of cytochemical stains. Alkaline phosphatase (ALP) was applied to Wright-Giemsa-stained cytology slides, and Factor VIII immunohistochemistry was evaluated. Cytologic characteristics included atypical mesenchymal cells with evidence of acute and chronic hemorrhage. Telangiectatic osteosarcoma cases had positive ALP cytochemical staining, while control HSA cases were negative. Factor VIII immunohistochemistry was negative in telangiectatic osteosarcoma and positive in HSA. Cytologic diagnosis of telangiectatic osteosarcoma with positive ALP cytochemical staining can help differentiate this neoplasm from HSA.
Keyphrases
  • fine needle aspiration
  • stem cells
  • high grade
  • oxidative stress
  • cell proliferation
  • photodynamic therapy
  • flow cytometry
  • cell cycle arrest