Distinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy.
Damián E Pérez-MazliahMelisa D Castro EiroMaría Gabriela ÁlvarezBruno LococoGraciela BertocchiGonzalo CésarMaría Ailén NataleMaría C AlbaredaRodolfo ViottiSusana Adriana LaucellaPublished in: PLoS neglected tropical diseases (2018)
The different clinical stages of chronic Chagas disease display distinct monocyte profiles that are restored after anti-parasite drug therapy. T. cruzi-infected subjects with severe cardiac disease displayed a profile of monocytes subsets suggestive of a more pronounced inflammatory environment compared with subjects suffering from heart failure not related to T. cruzi infection, supporting that parasite persistence might also alter cell components of the innate immune system.
Keyphrases
- heart failure
- peripheral blood
- dendritic cells
- immune response
- drug induced
- left ventricular
- endothelial cells
- single cell
- cell therapy
- plasmodium falciparum
- emergency department
- early onset
- toxoplasma gondii
- atrial fibrillation
- stem cells
- mesenchymal stem cells
- acute heart failure
- smoking cessation
- replacement therapy