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Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol.

Linea Natalie ToksvangBodil Als-NielsenChristopher BaconRuta BertasiuteXimo DuarteGabriele EscherichElín Anna HelgadottirInga Rinvoll JohannsdottirÓlafur G JónssonPiotr KozlowskiCecilia LangenskjöldKristi LepikRiitta NiinimäkiUlrik Malthe OvergaardMari PunabRiikka RätyHeidi SegersInge van der SluisOwen Patrick SmithMarion StrulluGoda VaitkevičienėHilde Skuterud WikMats HeymanKjeld Schmiegelow
Published in: BMC cancer (2022)
EudraCT, 2018-001795-38. Registered 2020-05-15, Clinicaltrials.gov , NCT04307576 . Registered 2020-03-13, https://clinicaltrials.gov/ct2/show/NCT04307576.
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