Biological effects of passive scattering and spot scanning proton beams at the distal end of the spread-out Bragg peak in single cells and multicell spheroids.

Kento NomuraHiromitsu IwataToshiyuki ToshitoChihiro OmachiJunpei NagayoshiKoichiro NakajimaHiroyuki OginoYuta Shibamoto

Published in: International journal of radiation biology (2021)

In single cells and spheroids, the effects of proton irradiation were stronger than expected from measured physical doses at the distal end of SOBP and were correlated with LET increases.

Keyphrases

induced apoptosis
cell cycle arrest
minimally invasive
mental health
physical activity
cell death
high resolution
radiation therapy
pi k akt
mass spectrometry
electron microscopy