Maintenance or Discontinuation of Antidepressants in Primary Care.
Gemma LewisLouise MarstonLarisa DuffyNick FreemantleSimon GilbodyRachael HunterTony KendrickDavid KesslerDee ManginMichael KingPaul LanhamMichael MooreIrwin NazarethNicola WilesFaye BaconMolly BirdSally BrabynAlison BurnsCaroline S ClarkeAnna HuntJodi PervinGlyn LewisPublished in: The New England journal of medicine (2021)
Among patients in primary care practices who felt well enough to discontinue antidepressant therapy, those who were assigned to stop their medication had a higher risk of relapse of depression by 52 weeks than those who were assigned to maintain their current therapy. (Funded by the National Institute for Health Research; ANTLER ISRCTN number, ISRCTN15969819.).