Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
Amani M Al-AmodiNeda Z GhanemSumayh A AldakeelLubna Ibrahim Al AsoomNazish Rafique AhmedNoor Barak AlmandilZaki A NaserullahSana Al-JarrashMohammed Shakil AkhtarSayed AbdulazeezAmein K Al-AliJesu Francis BorgioPublished in: Current medical research and opinion (2018)
Given the percentage of samples falling in the HbA2 "borderline" and "normal" categories, it can be concluded that HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers.