Intervertebral Disc Degeneration Induced by Needle Puncture and Ovariectomy: A Rat Coccygeal Model.

Tao Tian Haidong Wang Zhaohui Li Sidong Yang Wenyuan Ding

Published in: BioMed research international (2021)

The combination of ovariectomy and needle puncture can synergically induce IVDD in rat coccygeal discs. Estrogen treatment can effectively ameliorate IVDD progression in the newly established IVDD models.

Keyphrases

ultrasound guided
bone loss
oxidative stress
estrogen receptor
combination therapy