17-AAG Induces Endoplasmic Reticulum Stress-mediated Apoptosis in Breast Cancer Cells, Possibly Through PERK/eIF2α Up-regulation.

Prasit SuwannalertPimchanok PanpinyapornPitchapa WantanachaisaengTeerapat TeeppaibulThanaphat WorawichitchaikunThidarat KoomsangChonnapat NaktubtimWitchuda Payuhakrit

Published in: In vivo (Athens, Greece) (2024)

HSP90 emerges as a potential target for inducing apoptosis in breast cancer cells by disrupting protein homeostasis in the endoplasmic reticulum, possibly through PERK/eIF2α up-regulation. 17-AAG, an HSP90 inhibitor, may therefore potentially hold an alternative therapeutic strategy for breast cancer treatment.

Keyphrases

endoplasmic reticulum stress
breast cancer cells
endoplasmic reticulum
induced apoptosis
heat shock protein
heat shock
heat stress
binding protein
human health