Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.
Peter R MillarBrian A GordonJulie K WischStephanie A SchultzTammie Ls BenzingerCarlos CruchagaJason J HassenstabLaura IbanezCeleste KarchJorge J Llibre-GuerraJohn C MorrisRichard J PerrinCharlene Supnet-BellChengjie XiongRicardo F AllegriSarah B BermanJasmeer P ChhatwalPatricio A Chrem MendezGregory S DayAnna HofmannTakeshi IkeuchiMathias JuckerJae-Hong LeeJohannes LevinFrancisco LoperaYoshiki NiimiVictor J Sánchez-GonzálezPeter R SchofieldAna Luisa Sosa-OrtizJonathan Vögleinnull nullRandall J BatemanBeau M AncesEric M McDadePublished in: Molecular neurodegeneration (2023)
We extend prior work using BAG from sporadic AD to ADAD, noting consistent results. BAG associates well with markers of pTau, neurodegeneration, and cognition, but to a lesser extent, amyloid, in ADAD. BAG may capture similar signal to established MRI measures. However, BAG offers unique benefits in simplicity of data processing and interpretation. Thus, results in this unique ADAD cohort with few age-related confounds suggest that brain aging attributable to AD neuropathology can be accurately quantified from minimally-processed MRI.