NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition.

Ilya Iryani MahmodIntan Safinar IsmailNoorjahan Banu AlitheenYahaya M NormiFaridah AbasAlfi Khatibnull RudiyantoJalifah Latip

Published in: BMC complementary medicine and therapies (2020)

The C. nutans aqueous extract (1000 μg/mL) exhibited the most potential nephroprotective effect against cisplatin toxicity on NRK-52E cell lines at 89% of viability. The protective effect could be seen through the changes of the metabolites such as choline, alanine and valine in the C. nutans pre-treated samples with those of the cisplatin-induced group.

Keyphrases

oxidative stress
magnetic resonance
high resolution
ms ms
ionic liquid
liquid chromatography
solid state
drug induced
risk assessment
climate change