A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2'-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients.
Yuto MatsushitaYuji IwashitaShunsuke OhtsukaIppei OhnishiTakashi YamashitaHideaki MiyakeHaruhiko SugimuraPublished in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2021)
The present results revealed a reduction of 5hmdC levels in the non-tumoral urinary tract mucosa of patients with upper urinary tract urothelial carcinoma. Therefore, the urothelial cell epithelia of patients with upper urinary tract cancer, even in non-cancerous areas, may be predisposed to urothelial cancer.