Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.
Mark K BakkerJos P KanningGad AbrahamAmy E MartinsenBendik Slagsvold WinsvoldJohn-Anker ZwartRomain BourcierTomonobu SawadaMasaru KoidoYoichiro KamataniSandrine MorelPhillippe AmouyelStephanie DebettePhilippe BijlengaTakiy-Eddine BerrandouSanthi K GaneshNabila Bouatia-NajiGregory T JonesMatthew J BownGabriel J E RinkelJan Herman VeldinkYnte M Ruigroknull nullPublished in: Stroke (2023)
The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH.