Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients.

Teofila SeremetAlexander KochYanina JansenMax SchreuerSofie WilgenhofVéronique Del MarmolDanielle LiènardKris ThielemansKelly SchatsMark KockxWim Van CriekingePierre G CoulieTim De MeyerNicolas van BarenBart Neyns

Published in: Journal of translational medicine (2016)

Combined analyses of melanoma metastases with IHC, gene expression and methylation profiling can potentially identify durable responders to Ipi-based immunotherapy.

Keyphrases

gene expression
dna methylation
ejection fraction
newly diagnosed
small cell lung cancer
stem cells
squamous cell carcinoma
genome wide
systemic lupus erythematosus
single molecule
ulcerative colitis