Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects.

Kang XuYongqiang ShaSixiang WangQingjia ChiYanju LiuChunli WangLi Yang

Published in: Cell proliferation (2019)

Bakuchiol demonstrated significant bioactivity towards chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by estrogen receptor activation and exhibited enhanced promotion of the remodelling of injured cartilage.

Keyphrases

estrogen receptor
signaling pathway
pi k akt
stem cells
cell proliferation
total knee arthroplasty
extracellular matrix
knee osteoarthritis