Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis.

Nicolette W DuijvisPerry D MoerlandCindy KunneMonique M W SlamanFaas H van DoorenEsther W VogelsWouter J de JongeSybren L MeijerKees FluiterAnje A Te Velde

Published in: PloS one (2017)

In conclusion, CD4+CD45RBhi-transfer colitis induces miR-142-5p. Blocking miR-142-5p reduced colitis and prevented wasting disease, possibly by activation of the IL10RA pathway.

Keyphrases

mouse model
ulcerative colitis
rheumatoid arthritis
ankylosing spondylitis
disease activity
systemic lupus erythematosus
systemic sclerosis