Applications of machine learning in decision analysis for dose management for dofetilide.
Andrew E LevyMinakshi BiswasRachel WeberKhaldoun TarakjiMina ChungPeter A NoseworthyChristopher Newton-ChehMichael Aaron RosenbergPublished in: PloS one (2019)
Dose adjustments are a strong determinant of whether patients are able to successfully initiate dofetilide. A reinforcement learning algorithm informed by unsupervised learning was able to predict dosing decisions with 96.1% accuracy. Future studies will apply this algorithm prospectively as a data-driven decision aid.