Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT-enhanced estimate of renal function.
Laura Molenaar-KuijstenT T PietersW B VeldhuisP MoeskopsE J RijkhorstT P C DorloJ H BeijnenN SteeghsM B RookmaakerA D R HuitemaPublished in: British journal of clinical pharmacology (2023)
Carboplatin clearance is better predicted by CRAFT versus CG based CRCL. In subjects with low serum creatinine, the calculated carboplatin dose using CG exceeds the dose using CRAFT, which might explain the need for dose capping when using the CG. Therefore, the CRAFT might be an alternative for dose capping while still dosing accurately.