Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.

Zongzhe XuanQiuyue PengThomas LarsenLeonid GurevichJesper de Claville ChristiansenVladimir ZacharCristian Pablo Pennisi

Published in: Tissue engineering and regenerative medicine (2022)

Adjusting the composition of GelMA/alginate hydrogels is an effective means of controlling the SMC phenotype. These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.

Keyphrases

smooth muscle
drug delivery
hyaluronic acid
wound healing
urinary incontinence