Brain Regional Differences in Hexanucleotide Repeat Length in X-Linked Dystonia-Parkinsonism Using Nanopore Sequencing.

Charles Jourdan ReyesBjörn-Hergen LaabsSusen SchaakeTheresa LüthRaphaela ArdicogluAleksandar RakovicKaren GrützDaniel Alvarez-FischerRoland Dominic JamoraRaymond L RosalesImke WeyersInke Regina KönigNorbert BrüggemannChristine KleinValerija DobricicAna WestenbergerJoanne Trinh

Published in: Neurology. Genetics (2021)

Somatic repeat instability may predominate in brain regions selectively affected in XDP, thereby hinting at its potential role in disease manifestation and modification.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
early onset
single cell
single molecule
parkinson disease
copy number
dna methylation
brain injury
solid state
subarachnoid hemorrhage