Total flavone of Abelmoschus manihot regulates autophagy through the AMPK/mTOR signaling pathway to treat intestinal fibrosis in Crohn's disease.

Dan ZhangJiali LiuLei LvXiaopin ChenYunzhi QianPeizhen ZhaoQiaofeng ZhangYugen ChenHai-Hua Qian

Published in: Journal of gastroenterology and hepatology (2024)

TFA regulates autophagy through AMPK/mTOR signaling pathway to treat intestinal fibrosis, which may provide a new therapy for Crohn's disease treatment.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
cell death
epithelial mesenchymal transition
endoplasmic reticulum stress
cell proliferation
skeletal muscle
oxidative stress
protein kinase
liver fibrosis
combination therapy