Interleukin-32θ inhibits tumor-promoting effects of macrophage-secreted CCL18 in breast cancer.
Thu-Huyen PhamYesol BakTaeho KwonSae-Bom KwonJae-Wook OhJong-Hyung ParkYang-Kyu ChoiJin Tae HongDo-Young YoonPublished in: Cell communication and signaling : CCS (2019)
Our findings demonstrate a novel role of IL-32θ as an intracellular modulator to suppress macrophage-promoted breast cancer progression by targeting CCL18-dependent signaling.