Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment.

Alison E ObrSushil KumarYun-Juan ChangJoseph J BulatowiczBetsy J BarnesRaymond B BirgeDeborah A LazzarinoEmily GallagherDerek LeRoithTeresa L Wood

Published in: Breast cancer research : BCR (2018)

Our data support the hypothesis that reduction of IGF-1R function increases cellular stress and cytokine production to promote an aggressive tumor microenvironment through infiltration of immune cells and matrix remodeling.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
growth hormone
electronic health record
big data
pi k akt
binding protein
stress induced
signaling pathway
data analysis
heat stress