eQTL discovery and their association with severe equine asthma in European Warmblood horses.
Victor C MasonRobert J SchaeferMolly E McCueTosso LeebVinzenz GerberPublished in: BMC genomics (2018)
Thousands of genetic variants regulate gene expression in PBMCs of European Warmblood horses in cis and trans. Most high confidence eSNPs are significantly enriched near the transcription start sites of their target genes. Two trans regulatory hotspots on chromosome 11 and 13 regulate many genes involved in transmembrane cell signaling and neurological development respectively when PBMCs are treated with HDE. None of the top fifteen RAO associated SNPs strongly influence disease status through gene expression regulation.
Keyphrases
- gene expression
- dna methylation
- genome wide
- transcription factor
- single cell
- chronic obstructive pulmonary disease
- small molecule
- lung function
- copy number
- cell therapy
- early onset
- high throughput
- stem cells
- genome wide identification
- drug induced
- newly diagnosed
- brain injury
- bioinformatics analysis
- genome wide association
- blood brain barrier
- genome wide analysis