Regulation of MEK inhibitor selumetinib sensitivity by AKT phosphorylation in the novel BRAF L525R mutant.

Chikako NakaiSachiyo MimakiKoutatsu MatsushimaEiji ShinozakiKentaro YamazakiKei MuroKensei YamaguchiTomohiro NishinaSatoshi YukiKohei ShitaraHideaki BandoYutaka SuzukiKiwamu AkagiShogo NomuraSatoshi FujiiMasaya SugiyamaNao NishidaMasashi MizokamiYasuhiro KohTakuya KoshizakaHideki OkadaYukiko AbeAtsushi OhtsuTakayuki YoshinoKatsuya Tsuchihara

Published in: International journal of clinical oncology (2023)

We established a model system harboring BRAF L525R using HEK293 cells. BRAF L525R constitutively activated ERK. AKT phosphorylation caused sensitivity and resistance to selumetinib. Our results suggest that a comprehensive network analysis may provide insights to identify effective therapies.

Keyphrases

signaling pathway
network analysis
wild type
induced apoptosis
cell proliferation
pi k akt
metastatic colorectal cancer
cell cycle arrest
protein kinase