hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis.

Jing XiongTongyu LiuLin MiHenry KuangXuelian XiongZhimin ChenSiming LiJiandie D Lin

Published in: Hepatology (Baltimore, Md.) (2020)

These findings illustrate a mechanism through which disruptions of chromatin architecture drive the emergence of disease-specific signaling patterns that promote liver injury and exacerbate NASH pathogenesis.

Keyphrases

liver injury
drug induced
dna damage
gene expression
transcription factor
genome wide
cell cycle
oxidative stress
dna methylation