Genomic events stratifying prognosis of early gastric cancer.
Chiara MolinariLeonardo SolainiFrancesca RebuzziGianluca TedaldiDavide AngeliElisabetta PetracciDusan PrascevicJan EwaldErhard RahmMatteo CanaleMartinelli GiovanniAnna TomezzoliMaria BencivengaMaria Raffaella AmbrosioDaniele MarrelliPaolo MorgagniGiorgio ErcolaniPaola UliviLuca SaragoniPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)
We found that the most aggressive subtype Pen A is characterized by a higher frequency of ARID1A mutations and a higher genetic instability, while LRP1B alterations seem to be related to a lower disease-free survival. Further investigations are needed to provide a rationale for the use of these markers to stratify prognosis in EGC patients.