Prenylated Bibenzyls from the Chinese Liverwort Radula constricta and Their Mitochondria-Derived Paraptotic Cytotoxic Activities.
Chun-Yang ZhangYun GaoRong-Xiu ZhuYa-Nan QiaoJin-Chuan ZhouJiao-Zhen ZhangYi LiSi-Wen LiSheng-Hua FanHong-Xiang LouPublished in: Journal of natural products (2019)
Nine new prenylated bibenzyls, radstrictins A-I (1-9), and 11 known congeners were obtained from the Chinese liverwort Radula constricta. Their structures were identified by analysis of HRMS, NMR, and electronic circular dichroism data. Radstrictins A-F (1-6) were isolated as a racemate or scalemic mixtures. All the isolated compounds were subjected to cytotoxicity assessment. Methyl 2,4-dihydroxy-3-(3-methyl-2-butenyl)-6-phenethylbenzoate (10) exhibited significant activity against human lung cancer cell lines A549 and NCI-H1299 with IC50 values of 6.0 and 5.1 μM, respectively. Further research revealed that cell death triggered by 10 occurred via mitochondria-derived paraptosis.
Keyphrases
- cell death
- endothelial cells
- high resolution
- magnetic resonance
- cell cycle arrest
- reactive oxygen species
- electronic health record
- endoplasmic reticulum
- induced pluripotent stem cells
- ionic liquid
- single cell
- big data
- high resolution mass spectrometry
- machine learning
- artificial intelligence
- mass spectrometry
- simultaneous determination
- pi k akt