First evaluation of the Next-Generation Sequencing platform for the detection of HIV-1 drug resistance mutations in Belgium.
Géraldine DessillyLéonie GoeminneAnne-Thérèse VandenbrouckeFrançois E DufrasneAnandi MartinBenoît Kabamba-MukadiPublished in: PloS one (2018)
This is the first preliminary evaluation in Belgium employing the Sentosa SQ HIV Genotyping Assay. The NGS appears to be a promising tool for the detection of DRMs in HIV-1 patients and showed a higher sensitivity compared to SS. Large studies assessing the clinical relevance of low frequency DRMs are needed.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv testing
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- high throughput
- men who have sex with men
- end stage renal disease
- chronic kidney disease
- ejection fraction
- loop mediated isothermal amplification
- south africa
- label free
- genome wide
- copy number
- prognostic factors
- genetic diversity