Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN.

M E JoosseM A AardoomP KemosD TurnerD C WilsonS KoletzkoJ Martin-de-CarpiU L FagerbergC SprayC TzivinikosM SladekR ShaoulE Roma-GiannikouJ BronskyD E SerbanF M RuemmeleH Garnier-LenglineG VeresI HojsakK L KolhoI H DaviesM AloiP LionettiS HusseyG VeeremanC P BraeggerE TrindadeA V WewerA C HauerA C H de VriesR Sigall BonehC Sarbagili ShabatA LevineLissy de Riddernull null

Published in: Alimentary pharmacology & therapeutics (2018)

We report the largest number of paediatric-onset IBD patients with cancer and/or fatal outcomes to date. Malignancies followed by infections were the major causes of mortality. We identified PSC as a significant risk factor for cancer-associated mortality. Disease-related adenocarcinomas were a commoner cause of death than lymphomas.

Keyphrases

intensive care unit
cardiovascular events
emergency department
risk factors
ulcerative colitis
type diabetes
cardiovascular disease
metabolic syndrome
skeletal muscle