Expansion of HLA-DR Positive Peripheral Helper T and Naive B Cells in Anticitrullinated Protein Antibody-Positive Individuals At Risk for Rheumatoid Arthritis.
Hideto TakadaM Kristen DemoruelleKevin D DeaneShohei NakamuraYasuhiro KatsumataKatsunori IkariJane H BucknerWilliam H RobinsonJennifer A SeifertMarie L FeserLauraKay MossJill M NorrisMasayoshi HarigaiElena W Y HsiehV Michael HolersYuko OkamotoPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
naive B cells in ACPA+ individuals, including those who developed inflammatory arthritis and classified RA, supports a key role of these cells in transition from pre-RA to classified RA. These findings may identify a new mechanistic target for treatment and prevention in RA.