Atypical lymphoid cells circulating in blood in COVID-19 infection: morphology, immunophenotype and prognosis value.

Anna MerinoAlexandru VlageaAngel MolinaNatalia EgriJavier LagunaKevin BarreraLaura BoldúAndrea AcevedoMar Díaz-PavónFrancesc SibinaFrancisca BascónOriol SibilaManel JuanJosé Rodellar

Published in: Journal of clinical pathology (2020)

We found that COVID-19 RL are related to a better evolution and prognosis. They can be detected by morphology in the smear review, being the computerised approach proposed useful to enhance a more objective recognition. Their presence suggests an abundant production of virus-specific T cells, thus explaining the better outcome of patients showing these cells circulating in blood.

Keyphrases

induced apoptosis
cell cycle arrest
end stage renal disease
coronavirus disease
newly diagnosed
ejection fraction
endoplasmic reticulum stress
signaling pathway
cell death
cell proliferation
pi k akt
patient reported