A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers.
Adriano R TonelliKulwant S AulakMostafa K AhmedAlfred HausladenBatool AbuhalimehCharlie J CasaStephen Colin RogersDavid TimmAllan DoctorBenjamin GastonRaed A DweikPublished in: PloS one (2019)
Both nitrite and SNO-Hb increase during NO inhalation. Nitrite increases first, followed by a more sustained increase in Hb-SNO. Nitrite and Hb-SNO could be a mobile reservoir of NO with potential implications on the systemic microvasculature.