A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.

Michael T BromanRangarajan D NadadurCarlos Perez-Cervantes Ozanna Burnicka-TurekSonja LazarevicAnna GamsBrigitte LaforestJeffrey D SteimleSabrina IddirZhezhen WangLinsin SmithStefan R MazurekHarold E OliveyPingzhu Zhou Margaret Gadek Kaitlyn M ShenZoheb KhanJoshua W M Theisen Xinan Holly Yang Kohta Ikegami Igor R Efimov William T Pu Christopher R Weber Elizabeth M McNallyEric C SvenssonIvan P Moskowitz

Published in: Circulation (2024)

Transcriptional changes in the atria observed in human HF directly antagonize the atrial rhythm gene regulatory network, providing a genomic link between HF and AF risk independent of atrial remodeling.

Keyphrases

atrial fibrillation
heart failure
catheter ablation
left atrial
oral anticoagulants
left atrial appendage
direct oral anticoagulants
transcription factor
endothelial cells
percutaneous coronary intervention
copy number
left ventricular
coronary artery disease
dna methylation
genome wide