Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.

Madhurima ChatterjeeMarta Del CampoTjado H J MorremaMatthijs de WaalWiesje M van der FlierJeroen J M HoozemansCharlotte E Teunissen

Published in: Alzheimer's research & therapy (2018)

Taken together, these data reveal that the contactin-2 changes observed in tissues are reflected in CSF, suggesting that decreased contactin-2 CSF levels might be a biomarker reflecting synaptic or axonal loss.

Keyphrases

cerebrospinal fluid
spinal cord injury
prefrontal cortex
electronic health record
gene expression
white matter
cognitive decline
optic nerve
resting state
single cell
binding protein
multiple sclerosis
machine learning
blood brain barrier