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Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers.

Mica T M ClarkeFrédéric St-OngeJean-Mathieu BeauregardMartina BocchettaEmily ToddDavid M CashJonathan D RohrerRobert Laforce
Published in: Alzheimer's research & therapy (2021)
Anterior cingulate hypometabolism and atrophy are both apparent presymptomatically in a cohort of P301L MAPT mutation carriers. Such a specific marker may prove to be helpful in stratification of presymptomatic mutation carriers in future trials.
Keyphrases
  • functional connectivity
  • current status
  • magnetic resonance imaging
  • computed tomography