Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers.
Mica T M ClarkeFrédéric St-OngeJean-Mathieu BeauregardMartina BocchettaEmily ToddDavid M CashJonathan D RohrerRobert LaforcePublished in: Alzheimer's research & therapy (2021)
Anterior cingulate hypometabolism and atrophy are both apparent presymptomatically in a cohort of P301L MAPT mutation carriers. Such a specific marker may prove to be helpful in stratification of presymptomatic mutation carriers in future trials.