Login / Signup

Additively manufactured customized microhelix motors' bursting motion in mesoscopic tubes for vessel declogging.

Yang CaoHongyu YiKongyu GeYifan GaoZhenchao ZhangHuanhuan Feng
Published in: RSC advances (2024)
Magnetic microhelix motors are widely employed in various applications such as cargo transportation, drug delivery, toxic substance declogging, and cell manipulation, due to their unique adaptive magnetic manipulation capabilities. In this work, high-precision stereoscopic additive manufacturing techniques were used to produce customized microhelices with varying structural parameters, including different pitch numbers (2-4 pitches), sizes (0.1-0.25 mm), and taper angles (172°-180°). Their motion performance in mesoscopic tubes was systematically investigated. The magnetic microhelix motors' speed increases when circle numbers and taper angles decrease, while circle diameters increase. The magnetic microhelix motors' speed could achieve a 1500% enhancement reaching 0.16 mm s -1 in a 0.3 mm tube, with a pitch number of 3, diameter of 0.2 mm, and taper angle of 172°. Furthermore, their vessel declogging capability is confirmed in in vitro experiments.
Keyphrases
  • molecularly imprinted
  • drug delivery
  • high resolution
  • image quality
  • magnetic resonance
  • magnetic resonance imaging
  • cancer therapy
  • mass spectrometry
  • optic nerve
  • drug release