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E-GWAS: an ensemble-like GWAS strategy that provides effective control over false positive rates without decreasing true positives.

Guang-Liang ZhouFang-Jun XuJia-Kun QiaoZhao-Xuan CheTao XiangXiao-Lei LiuXin-Yun LiShu-Hong ZhaoMeng-Jin Zhu
Published in: Genetics, selection, evolution : GSE (2023)
Using both simulated and real datasets, we show that E-GWAS is a reliable and robust strategy that effectively integrates the GWAS results of different methods and reduces the number of false positive SNPs without decreasing that of true positive SNPs.
Keyphrases
  • genome wide
  • gene expression
  • dna methylation
  • machine learning
  • convolutional neural network
  • genome wide association