New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis.
Gizele Cabral CostaTadeu Lima MontagnoliJaqueline Soares da SilvaAllan Kardec Nogueira de AlencarLuis Eduardo Reina GambaBryelle Eccard Oliveira AlvesMarina Moraes Carvalho da SilvaMargarete Manhães TrachezJose Hamilton Matheus NascimentoPedro Moreno Pimentel-CoelhoRosália Mendez-OteroLidia Moreira LimaEliezer Jesus BarreiroRoberto Takashi SudoGisele Zapata-SudoPublished in: Drug design, development and therapy (2020)
LASSBio-2090 alleviates metabolic disturbance and cardiomyopathy in an obese and diabetic rat model, thus representing a novel strategy for the treatment of cardiovascular complications in obesity-associated type 2 diabetes mellitus.
Keyphrases
- weight loss
- type diabetes
- metabolic syndrome
- adipose tissue
- insulin resistance
- bariatric surgery
- glycemic control
- obese patients
- rheumatoid arthritis
- heart failure
- risk factors
- weight gain
- oxidative stress
- cardiovascular risk factors
- high fat diet induced
- mouse model
- body mass index
- wound healing
- atrial fibrillation
- skeletal muscle
- physical activity
- smoking cessation