Metformin serum concentrations during pregnancy and post partum - A clinical study in patients with polycystic ovary syndrome.

Ketil Arne Espnes Arne Hønnås Tone S Løvvik Per Ole M Gundersen Audhild Naavik Eirik Skogvoll Andreas Austgulen Westin Olav Spigset Eszter Vanky

Published in: Basic & clinical pharmacology & toxicology (2022)

Clinicians who treat pregnant women with metformin should be aware of the significant decrease in metformin concentration mediated by pregnancy, and the rapid increase after delivery, as it may impact both the therapeutic efficacy and the risk of adverse drug reactions.

Keyphrases

adverse drug
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
pregnant women
emergency department
clinical trial
patient reported outcomes
drug induced