Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia.

Lene KarlssonCharlotte Guldborg NyvoldAnastasia SoboliPegah JohanssonLars PalmqvistAnne Tierens Henrik HasleBirgitte LausenÓlafur Gisli JónssonGitte Wulff JürgensenLene Hyldahl EbbesenJonas Abrahamsson Linda Fogelstrand

Published in: International journal of laboratory hematology (2022)

Measurement with RT-qPCR suggests slower response kinetics than indicated from MFC, presumably due to the presence of mature cells expressing fusion transcript. The prognostic impact of early measurements with RT-qPCR remains to be determined.

Keyphrases

flow cytometry
induced apoptosis
rna seq
liver failure
bone marrow
acute myeloid leukemia
cell cycle arrest
respiratory failure
immune response
endoplasmic reticulum stress
signaling pathway
hepatitis b virus
single cell
mechanical ventilation
acute respiratory distress syndrome