Topography of 11C-Pittsburgh compound B uptake in Alzheimer's disease: a voxel-based investigation of cortical and white matter regions.

Daniele de Paula FariaFabio L DuranPaula SquarzoniArtur M CoutinhoAlexandre T GarcezPedro P SantosSonia M BruckiMaira O de OliveiraEduardo S TrésOrestes V ForlenzaRicardo NitriniCarlos A BuchpiguelGeraldo Filho Busatto

Published in: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) (2018)

The present case-control voxelwise 11C-PIB PET comparison highlighted the regional distribution of amyloid deposition in the cerebral cortex of mildly demented AD patients. Tracer uptake was highest in the orbitofrontal cortex. Decreased 11C-PIB uptake in white-matter regions in this patient population may be a marker of white-matter damage in AD.

Keyphrases

white matter
pet imaging
multiple sclerosis
end stage renal disease
case control
newly diagnosed
positron emission tomography
functional connectivity
chronic kidney disease
computed tomography
oxidative stress
peritoneal dialysis
cognitive decline
patient reported outcomes
blood brain barrier
cerebral blood flow