A nerve conduit filled with Wnt5a-loaded fibrin hydrogels promotes peripheral nerve regeneration.
Yi-Jun LiuXiao-Feng ChenYongqiang WenFeng RaoDian-Ying ZhangYan-Hua WangPublished in: CNS neuroscience & therapeutics (2021)
The Wnt5a/Fn nerve conduit can promote peripheral nerve defect regeneration, with potential clinical applications. The mechanism for this may be the facilitation of multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.